Ashish Sharma, PhD

Ashish Sharma Ph.D. is a Deputy Director of the Bioinformatics and Integrated Systems Biology (BISB) core for the TRAC. He is an Instructor in the Department of Pathology and Laboratory Medicine at the Emory University School of Medicine. His primary research interest is applying systems immunology approches to understand disease progression and success of vaccines and immunotherapeutics in infectious diseases including tuberculosis. Dr. Sharma uses high-throughput cellular and molecular profiling techniques to better understand human health and disease pathophysiology with a goal of translating his findings to improve vaccines and identify immune mechanisms that drive disease progression that are amenable to host-directed therapies. His work to date has focused on using wet-lab and systems informatics approaches to model ex vivo human or non-human primates to understand infectious disease progression (TB, HIV, HBV), success of cell therapies in Caner/HIV (e.g. CAR-T cells) and development of the neonatal immune system to respond to infections such as bacterial sepsis, influenza and RSV.