Pathogenesis, Immunity and Comorbidities in Active TB Disease

Immunity

Active Awards
Immunometabolism of myeloid suppressor cell responses to M. tuberculosis in PWH: Jyothi RengarajanInvestigating alveolar macrophages in PLWH as targets for HIV persistence, residual inflammation and immune activation: Drs. Jyothi Rengarajan, Baek Kim and Bashar Staitieh
Deep spatial immune profiling of granulomas and M. tuberculosis adaptation to disease and treatment: Drs. Jyothi Rengarajan and Bree Beardsley
ACTG Laboratory Center: Emory Immunology Specialty Laboratory: Dr. Cheryl Day
Development of monoclonal antibodies for the study of Mycobacterium tuberculosis (Mtb) in the Guinea pig: Drs. Frederick Quinn and Tuhina Gupta
Completed Awards
Role of antigen-specific T cell responses in the control of TB: NIH TB Research Unit: Drs. Henry Blumberg, Cheryl Day, Jyothi Rengarajan, John Altman, Neel Gandhi, Lance Waller
The effect of HIV exposure and infection on immunity to TB in children: Dr. Cheryl Day
NK cell-mediated regulation of T cell immunity in TB/HIV co-infection: Dr. Cheryl Day
Mechanisms of antigen-specific CD4 T cell dysfunction in HIV/TB co-infection: Dr. Cheryl Day 
The effect of HIV infection on CD4 T cell immunity to Mycobacterium tuberculosis: Dr. Cheryl Day
Impact of concurrent HIV and latent TB therapies on M. tuberculosis-specific immune function: Dr. Jyothi Rengarajan
Innate-adaptive crosstalk in protective and vaccine-induced immunity to TB: Dr. Jyothi Rengarajan     
Impact of concurrent HIV and latent TB therapies on Mtb-specific immune function: Dr. Jyothi Rengarajan

Comorbidities

Active Awards
Multiomics Characterization of Micobiome and Immunometabolic REmodeling in Tuberculosis Stress Hyperglycemia: Drs. Jeffrey Collins, Matthew Magee and Ashish Sharma
Strengthening HIV-associated Non-Communicable Disease Research Capacity to Improve the Health of People Living in Mozambican Prisons: Anne Spaulding
Tuberculosis infection and risk of diabetes mellitus and cardiovascular disease: Epigenetic and cardiometabolic trajectories after TB infection: Drs. Matthew Magee, Moises Human and Yan Sun
NIH Vaccine Trials and Evaluation Units (VTEU): Drs. Nadine Rouphael, Daniel Graciaa, Carlos del Rio
NIH Clinical Trials Units: AIDS Clinical Trials Group (ACTG): Drs. Sarita Shah, Russell Kempker, Jeff Lennox, Carlos del Rio
Center for AIDS Research at Emory University (CFAR): Drs. Carlos del Rio, Ann Chahroudi, Colleen Kelley
Emory-CDC CTU: Drs. Colleen Kelley and Moises Huaman
Establishing a cystic fibrosis ferret model of chronic Mycobacterium abscessus lung infection: Drs. Balazs Rada, Tuhina Gupta and Frederick Quinn
Completed Awards
Coronary Atherosclerosis and Immune Activation in HIV and Tuberculosis Infection: Dr. Moises Huaman
Immunometabolic impact of stress hyperglycemia on tuberculosis treatment outcomes and risk of diabetes mellitus: Dr. Matthew Magee
The Role of Tuberculosis Disease on Non-Communicable Disease Risk: Dr. Matthew Magee
Latent TB Infection and Risk of Type 2 Diabetes Mellitus: Dr. Matthew Magee
Pulmonary impairment after tuberculosis in Georgia: Enhancing clinical research capacity to address the intersection of non-communicable diseases and tuberculosis: Drs. Maia Kipiani and Matthew Magee
Impact of HIV Infection on early responses to TB exposure: Dr. Sara Auld

Pathogenesis

Completed Awards
Illuminating Heme Trafficking and Signaling Pathways in Health and Disease: Dr. Amit Reddi
CellGraph: bioimaging software to rapidly identify bacterial genes responsible for modifications to host cell organelle morphology: Dr. Shannon Quinn